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The m1A-SFRP2-NFAT/TOX axis governs T cell exhaustion in gastric cancer

11 Aug 2025

Abstract excerpt

While immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, their efficacy in gastric cancer (GC) remains limited, underscoring the need for mechanistic biomarkers of immune evasion. We analyzed m 1 A RNA modification patterns in the TCGA-STAD cohort, stratifying patients into three subtypes. Functional assays (including CRISPR-based SFRP2 modulation, NFAT/TOX reporter systems, and ex vivo...

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PMID: 40788471
DOI: 10.1007/s13402-025-01096-z

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