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Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression

1 Apr 2025

Abstract excerpt

Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of differentiated, non-proliferative signet ring cells (SRCs). These indolent lesions can advance into highly proliferative and metastatic tumours, which requires suppression of DGC cell differentiation. Objective Our goal was to identify molecular changes contributing to the progression of...

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Identifiers

PMID: 40169243
DOI: 10.1136/gutjnl-2024-334589

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