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Article

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry.

Journal of translational medicine - 12 Oct 2017

Ying Le, Yan Feng, Meng Qiaohong, Yuan Xiangliang, Yu Liang, Williams Bryan R G, Chan David W, Shi Liyun, Tu Yugang, Ni Peihua, Wang Xuefeng, Xu Dakang, Hu Yiqun

Abstract excerpt

BACKGROUND: Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses. METHODS: We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1),...

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Identifiers

PMID: 29025424
DOI: 10.1186/s12967-017-1311-8
PMCID: PMC5639762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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