Article
Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis.
Molecular cancer research : MCR - 1 Dec 2023
Green Benjamin L, Gamble Lauren A, Diggs Laurence P, Nousome Darryl, Patterson Jesse C, Joughin Brian A, Gasmi Billel, Lux Stephanie C, Samaranayake Sarah G, Miettinen Markku, Quezado Martha, Hernandez Jonathan M, Yaffe Michael B, Davis Jeremy L
Abstract excerpt
Stage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells (SRC), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants and hereditary diffuse gastric cancer syndrome (HDGC). The molecular steps involved in initiating malignant transformation and promoting SRC dormancy in HDGC are unknown. Here, whole-exome bulk RNA sequencing (RNA-seq) of SRCs and...
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