Back to search

Article

CEACAM5/6 <sup>+</sup> Tumor Cells and IL-1β <sup>+</sup> Macrophages Drive Resistance to Chemo-immunotherapy in Gastric Cancer

2026-03-08

Abstract excerpt

Chemo-immunotherapy is a first-line treatment for advanced gastric cancer, yet response rates remain limited and resistance mechanisms are poorly defined. Here we generate a single-cell atlas of 542,121 cells from 35 patients treated with anti–PD-1 plus chemotherapy, profiling pre- and post-treatment tumors linked to clinical response. Integrating spatial transcriptomics, immunohistochemistry, and bulk RNA sequenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
aefa4c02-5e70-5a74-a126-b14b0c577440
DOI
10.64898/2026.03.05.708917
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CEACAM5/6 <sup>+</sup> Tumor Cells and IL-1β <sup>+</sup> Macrophages Drive Resistance to Chemo-immunotherapy in Gastric CancerDOI 10.64898/2026.03.05.708917
Single-cell RNA sequencing and large-scale bulk combination with machine learning reveal gastric cancer-related macrophage heterogeneitySemantic proximity
Tumor-Enriched VCAN⁺ Macrophages Induce CD8⁺ T-Cell Exhaustion via STAT3–SPP1 Axis in Gastric CancerSemantic proximity
Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironmentSemantic proximity
Transcriptomic characterization of CSF1R-high advanced gastric cancer identifies a poor- prognosis macrophage-rich subtypeSemantic proximity
Re-analysis of single cell and spatial transcriptomics data reveals B cell landscape in gastric cancer microenvironment and its potential crosstalk with tumor cells for clinical prognosisSemantic proximity
Single-cell profiling of gastric cancer ascites reveals immunosuppressive remodeling and an epithelial-immune dual phenotype signature predictive for PD-1 immunotherapy responsesSemantic proximity
Single-cell RNA sequencing revealed heterogeneity of the immune microenvironment in gastric cancerSemantic proximity
Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasionSemantic proximity
Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristicsSemantic proximity
Single-cell and spatial transcriptomic profiling reveals impaired tertiary lymphoid structure maturation associated with T cell exhaustion in gastric cancerSemantic proximity
Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer.Semantic proximity
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity
Select a neighboring publication to make it the new centre.