Back to search

Article

Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer

2025-05-06

Abstract excerpt

The gastric mucosa is characterized by continuous innate immune surveillance and inflammatory signaling, yet a high proportion of gastric carcinomas (GCs) are recalcitrant to immune-directed therapies. The mechanisms by which GCs evade adaptive immune surveillance within the highly antigenic microenvironment of the gastric mucosa remains unknown. To address this, we collected patient-matched tumor tissue, distant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c4c18c9a-f8f6-5724-a14a-c08665b37a7c
DOI
10.1101/2025.05.05.651897
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancerDOI 10.1101/2025.05.05.651897
scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectorySemantic proximity
Single-cell and spatial transcriptomic profiling reveals impaired tertiary lymphoid structure maturation associated with T cell exhaustion in gastric cancerSemantic proximity
Deciphering Tumor Microenvironment Dynamics in Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma using Single-cell RNA SequencingSemantic proximity
Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformationSemantic proximity
Dynamic single-cell mapping unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment responseSemantic proximity
Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancerSemantic proximity
CEACAM5/6 <sup>+</sup> Tumor Cells and IL-1β <sup>+</sup> Macrophages Drive Resistance to Chemo-immunotherapy in Gastric CancerSemantic proximity
Tumor-Infiltrating T Cells in EBV-Associated Gastric Carcinomas Exhibit High Levels of Multiple Markers of Activation, Effector Gene Expression, and ExhaustionSemantic proximity
Circulating inflammatory ILC2s as a biomarker of gastric cancer progressionSemantic proximity
Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer.Semantic proximity
The m1A-SFRP2-NFAT/TOX axis governs T cell exhaustion in gastric cancerSemantic proximity
The association of immune cell infiltration and prognostic value of tertiary lymphoid structures in gastric cancerSemantic proximity
Select a neighboring publication to make it the new centre.