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Article

Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation.

The American journal of surgical pathology - 1 Jun 2024

Rokutan Hirofumi, Arai Yasuhito, Kunita Akiko, Yamasaki Satoshi, Nakamura Hiromi, Hama Natsuko, Nakayama Atsuhito, Hosoda Fumie, Totoki Yasushi, Fujishiro Mitsuhiro, Seto Yasuyuki, Shibata Tatsuhiro, Ushiku Tetsuo

Abstract excerpt

Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a slow-growing neoplasm with an indolent clinical course; however, a subset demonstrates transformation into adenocarcinoma with higher-grade histology, typically diffuse-type...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to rhoA GTP-Binding Protein

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Source

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Identifiers

PMID: 38584451
DOI: 10.1097/PAS.0000000000002222
PMCID: PMC11093485

Genes

RHOA
ARHGAP26
ARID1A
CLDN18
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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