Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff

Abstract excerpt

Cytochrome P450s (CYPs) are a family of enzymes responsible for metabolizing nearly 80% of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which may result in improper dosing and severe adverse drug reactions. CYPs have low sequence conservation, making it difficult to anticipate whether variant effects measured in one CYP may extend to others based on sequence alone. Even closely r...

Topics

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• Amino Acid Substitution
• Cytochrome P-450 CYP2C19
• Cytochrome P-450 CYP2C9
• HEK293 Cells
• High-Throughput Nucleotide Sequencing
• Mutation
• Polymorphism, Single Nucleotide
• Substrate Specificity

Identifiers and source

Literature Corpus work

3dfcab11-98e7-59db-8508-561b5d95a39b

DOI

10.1101/2023.10.06.561250