Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers.

The Journal of pharmacology and experimental therapeutics - 19 Nov 2024

Kuchinski Kennedy, King Nathaniel, Driggers Julia, Lawson Kylie, Vo Martin, Skrtic Shayne, Slattery Connor, Lane Rebecca, Simone Emma, Mills Stephen A, Escorcia Wilber, Wetzel Hanna

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP450) enzymes alter the metabolism of a variety of drugs. Numerous medications, including chemotherapies, are metabolized by CYP450 enzymes, making the expression of this suite of enzymes in tumor cells relevant to prescription regimens for patients with cancer. We analyzed the characteristics of mutations of the cytochrome P450 2D6 (CYP2D6) enzymes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2D6
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39379142
DOI: 10.1124/jpet.124.002136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers.PMID 39379142Read ↗

Pan-Cancer Somatic Pharmacogenomic Variant Landscape: Cross-Referencing TCGA Somatic Mutations with PharmVar/CPIC Star-Allele Definitions Across CYP2D6, CYP2C19, DPYD, and TPMTSemantic proximity Read ↗

Pharmacogenomics in Solid Tumors: A Comprehensive Review of Genetic Variability and Its Clinical ImplicationsSemantic proximity Read ↗

PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting.Semantic proximity Read ↗

A Review of the Important Role of CYP2D6 in Pharmacogenomics.Semantic proximity Read ↗

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3DSemantic proximity Read ↗

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.Semantic proximity Read ↗

Loss of CYP2D6 sensitizes hepatocellular carcinomas and neuroblastomas to talazoparibSemantic proximity Read ↗

Genetic ancestral patterns in<i>CYP2D6</i>alleles: structural variants, rare variants, and clinical associations in 479,144 UK Biobank genomesSemantic proximity Read ↗

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzymeSemantic proximity Read ↗

PharmVar GeneFocus: <i>CYP2D6</i>Semantic proximity Read ↗

Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.Semantic proximity Read ↗

In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.