Article

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

2021-03-14

Abstract excerpt

<h4>ABSTRACT</h4> CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed to over 15 million people annually and polymorphisms in CYP2C9 can affect patient response leading to an increased risk of hemorrhage. We developed Click-seq,...

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Literature Corpus work: edf44e66-420c-5498-98cc-44c23de4c1e1
DOI: 10.1101/2021.03.12.435209

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