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Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2024

Avsar Orcun

Abstract excerpt

Genetic variations in the human cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily D member 6 (CYP2D6) genes may affect drug metabolism and lead to alterations in phenotypes. Genetic variations are associated with toxicity, adverse drug reactions, inefficient treatment. Various in silico tools were combined to investigate the deleterious effects of missense...

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PMID: 37747773
DOI: 10.1080/15257770.2023.2262519

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