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Article

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants.

Clinical and translational science - 1 Jul 2020

Zhang Lingxin, Sarangi Vivekananda, Moon Irene, Yu Jia, Liu Duan, Devarajan Sandhya, Reid Joel M, Kalari Krishna R, Wang Liewei, Weinshilboum Richard

Abstract excerpt

Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge for pharmacogenomics. Deep mutational scanning (DMS) is a high-throughput technique that makes it possible to analyze the functional effect of hundreds of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32004414
DOI: 10.1111/cts.12758
PMCID: PMC7359949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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