Article

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets

2023-05-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> SORCS2 is an intracellular sorting receptor genetically associated with body mass index (BMI) in humans, yet its mode of action remains unknown. Elucidating the receptor function that defines its role in metabolic health is the objective of this work. <h4>Methods</h4> Combining in vivo metabolic studies in SORCS2-deficient mouse models with ex vivo structural and functiona...

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Literature Corpus work: b8c00714-3e2e-59b2-a18b-8afa2628e6d2
DOI: 10.1101/2023.05.15.540791

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