Article

<i>Chop</i> / <i>Ddit3</i> depletion in β-cells alleviates ER stress and corrects hepatic steatosis

2020-01-03

Abstract excerpt

Type 2 diabetes ( T2D ) is a metabolic disorder characterized by hyperglycemia, hyperinsulinemia and insulin resistance ( IR ). During the early phase of T2D, insulin synthesis and secretion by pancreatic β cells is enhanced, which can lead to proinsulin ( ProIns ) misfolding that aggravates endoplasmic reticulum ( ER ) homeostasis in β cells. Moreover, increased insulin in the circulation may contribute to fa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4eb99ade-a09d-5105-8ca7-60f37cd387ed
DOI: 10.1101/2020.01.02.893271

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Chop</i> / <i>Ddit3</i> depletion in β-cells alleviates ER stress and corrects hepatic steatosisDOI 10.1101/2020.01.02.893271Read

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.Semantic proximity Read

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.Semantic proximity Read

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitusSemantic proximity Read

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.Semantic proximity Read

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity Read

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell ApoptosisSemantic proximity Read

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.Semantic proximity Read

IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cellsSemantic proximity Read