Article
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Science (New York, N.Y.) - 15 Oct 2004
Ozcan Umut, Cao Qiong, Yilmaz Erkan, Lee Ann-Hwee, Iwakoshi Neal N, Ozdelen Esra, Tuncman Gürol, Görgün Cem, Glimcher Laurie H, Hotamisligil Gökhan S
Abstract excerpt
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1...
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