Article

A murine model of the human CREBRF <sup>R457Q</sup> obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress

2021-05-06

Abstract excerpt

Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRF R457Q ] is strongly associated with increased odds of obesity but decreased odds of diabetes. Although virtually nothing is known about CREBRF’s mechanism of action, emerging evidence...

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Literature Corpus work: ead61adf-1b12-588b-a013-55fdb5ba1aa5
DOI: 10.1101/2021.05.06.442909

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