Article

Haplotype-phased synthetic long reads from short-read sequencing

2015-07-21

Abstract excerpt

Next-generation DNA sequencing has revolutionized the study of biology. However, the short read lengths of the dominant instruments complicate assembly of complex genomes and haplotype phasing of mixtures of similar sequences. Here we demonstrate a method to reconstruct the sequences of individual nucleic acid molecules up to 11.6 kilobases in length from short (150-bp) reads. We show that our method can construct...

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Literature Corpus work: 3daccc6b-64ae-5f50-8e66-2ec3d5f698ba
DOI: 10.1101/022897

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