Article

Strainline: full-length de novo viral haplotype reconstruction from noisy long reads

2021-07-04

Abstract excerpt

Haplotype-resolved de novo assembly of highly diverse virus genomes is critical in prevention, control and treatment of viral diseases. Current methods either can handle only relatively accurate short read data, or collapse haplotype-specific variations into consensus sequence. Here, we present Strainline, a novel approach to assemble viral haplotypes from noisy long reads without a reference genome. As a crucial...

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Literature Corpus work: 55d34a96-2d59-5532-b411-f54ff4ce17a9
DOI: 10.1101/2021.07.02.450893

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