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Article

BAsE-Seq: a method for obtaining long viral haplotypes from short sequence reads.

Genome biology - 1 Jan 2014

Hong Lewis Z, Hong Shuzhen, Wong Han Teng, Aw Pauline P K, Cheng Yan, Wilm Andreas, de Sessions Paola F, Lim Seng Gee, Nagarajan Niranjan, Hibberd Martin L, Quake Stephen R, Burkholder William F

Abstract excerpt

We present a method for obtaining long haplotypes, of over 3 kb in length, using a short-read sequencer, Barcode-directed Assembly for Extra-long Sequences (BAsE-Seq). BAsE-Seq relies on transposing a template-specific barcode onto random segments of the template molecule and assembling the barcoded short reads into complete haplotypes. We applied BAsE-Seq on mixed clones of hepatitis B virus and accurately...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25406369
DOI: 10.1186/PREACCEPT-6768001251451949
PMCID: PMC4269956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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