Algorithms for Short-Read Viral Haplotype Reconstruction: Challenges, Solutions, and Perspectives.

Abstract excerpt

RNA viruses, such as HIV, HCV, and SARS-CoV-2, show high levels of intrahost genetic diversity. Many different haplotypes can be present in a single infection, which can be studied using next-generation sequencing. However, full-length haplotype reconstruction from short reads is computationally challenging due to the presence of low-frequency mutants, as well as sequencing errors. Moreover, reads may not be long...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Computational Biology
• Share to COVID-19