Article

ACE I/D Polymorphism Modulates Restless Legs Syndrome Risk: Ancestry-Dependent Overdominance

2026-05-08

Abstract excerpt

<title>Abstract</title> <p> Background Restless legs syndrome (RLS) frequently co-occurs with cardiovascular and metabolic conditions, yet shared genetic mechanisms remain elusive. The angiotensin-converting enzyme (ACE) I/D polymorphism modulates these comorbidities but its relationship to RLS susceptibility is unknown. Methods We used a discovery-validation framework: (1) a polysomnography-confirmed clinical...

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Literature Corpus work: 3d6b0916-eac2-5b52-a7b4-395b7e365ca4
DOI: 10.21203/rs.3.rs-9624406/v1

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