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Article

Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large genome-wide association study dataset of European ancestry.

Sleep - 11 Aug 2022

Schormair Barbara, Zhao Chen, Salminen Aaro V, Oexle Konrad, Winkelmann Juliane

Abstract excerpt

STUDY OBJECTIVES: Several candidate gene studies have been published for idiopathic restless legs syndrome (RLS) in populations of European ancestry, but the reported associations have not been confirmed in independent samples. Our aim was to reassess these findings in a large case-control dataset in order to evaluate their validity. METHODS: We screened PubMed for RLS candidate gene studies. We used the...

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PMID: 35486972
DOI: 10.1093/sleep/zsac098
PMCID: PMC9366638

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