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Article

Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome.

Sleep - 1 Nov 2018

El Gewely Maryam, Welman Mélanie, Xiong Lan, Yin Sophie, Catoire Hélène, Rouleau Guy, Montplaisir Jacques Y, Desautels Alex, Warby Simon C

Abstract excerpt

Two genome-wide association studies (GWAS) suggest that insomnia and restless legs syndrome (RLS) share a common genetic basis. While the identified genetic variation in the MEIS1 gene was previously associated with RLS, the two GWAS suggest a novel and independent association with insomnia symptoms. To test the potential pleiotropic effect of MEIS1, we genotyped three MEIS1 variants in 646 chronic insomnia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30215811
DOI: 10.1093/sleep/zsy164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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