Article
Three Reportedly Unrelated Families With Liddle Syndrome Inherited From a Common Ancestor.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2018
Pagani Luca, Diekmann Yoan, Sazzini Marco, De Fanti Sara, Rondinelli Maurizio, Farnetti Enrico, Casali Bruno, Caretto Amelia, Novara Francesca, Zuffardi Orsetta, Garagnani Paolo, Mantero Franco, Thomas Mark G, Luiselli Donata, Rossi Ermanno
Abstract excerpt
Liddle syndrome is considered a rare Mendelian hypertension. We have previously described 3 reportedly unrelated families, native of an Italian area around the Strait of Messina, carrying the same mutation (βP617L) of the epithelial sodium channel. The aims of our study were (1) to evaluate whether a close genomic relationship exists between the 3 families through the analysis of mitochondrial DNA and Y...
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