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Article

Total Chemical Synthesis of Glycosylated TREM2 Ectodomain.

ACS chemical neuroscience - 7 Jun 2023

Wijegunawardena Gayani, Castillo Erika, Henrickson Brandy, Davis Regan, Condello Carlo, Wu Haifan

Abstract excerpt

Mutations in a microglia-associated gene TREM2 increase the risk of Alzheimer's disease. Currently, structural and functional studies of TREM2 mainly rely on recombinant TREM2 proteins expressed from mammalian cells. However, using this method, it is difficult to achieve site-specific labeling. Here, we present the total chemical synthesis of the 116 amino acid TREM2 ectodomain. Rigorous structural analysis...

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Identifiers

PMID: 37235776
DOI: 10.1021/acschemneuro.3c00257
PMCID: PMC10786670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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