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The human embryonic genome is karyotypically complex, with chromosomally abnormal cells preferentially located away from the developing fetus

9 Nov 2022

Abstract excerpt

STUDY QUESTION: Are chromosome abnormalities detected at Day 3 post-fertilization predominantly retained in structures of the blastocyst other than the inner cell mass (ICM), where chromosomally normal cells are preferentially retained? SUMMARY ANSWER: In human embryos, aneuploid cells are sequestered away from the ICM, partly to the trophectoderm (TE) but more significantly to the blastocoel fluid within the...

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PMID: 36350568
DOI: 10.1093/humrep/deac238

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