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Article

Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro.

Scientific reports - 29 Aug 2017

Ottolini Christian S, Kitchen John, Xanthopoulou Leoni, Gordon Tony, Summers Michael C, Handyside Alan H

Abstract excerpt

Following in vitro fertilisation (IVF), only about half of normally fertilised human embryos develop beyond cleavage and morula stages to form a blastocyst in vitro. Although many human embryos are aneuploid and genomically imbalanced, often as a result of meiotic errors inherited in the oocyte, these aneuploidies persist at the blastocyst stage and the reasons for the high incidence of developmental arrest...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28851957
DOI: 10.1038/s41598-017-09693-1
PMCID: PMC5575028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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