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Insights into embryonic chromosomal instability: mechanisms of DNA elimination during mammalian preimplantation development

4 Feb 2024

Abstract excerpt

Mammalian preimplantation embryos often contend with aneuploidy that arose either by the inheritance of meiotic errors from the gametes, or from mitotic mis-segregation events that occurred following fertilization. Regardless of the origin, mis-segregated chromosomes become encapsulated in micronuclei (MN) that are spatially isolated from the main nucleus. Much of our knowledge of MN formation comes from dividing...

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PMID: 38374891
DOI: 10.3389/fcell.2024.1344092

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