Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

Abstract excerpt

Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50–80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hypothesis that blastomere behaviour may reflect ploidy during the first two cleavage divisions. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosomal and Genetic Variations
• Share to Prenatal Screening and Diagnostics
• Share to Reproductive Biology and Fertility