Article

Evaluating the Impact of Principal Component and Mixed Model Approaches on Polygenic Risk Score Portability to Diverse Ancestries in the UK Biobank

2026-08-19

Abstract excerpt

Polygenic risk scores (PRS) offer considerable potential for precision medicine. However, their predictive performance often attenuates when applied to populations that differ from the genome-wide association study (GWAS) training population. There are many potential sources of this portability problem, and one relatively under-explored contributor is the presence of residual confounding in GWAS summary statistics...

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Literature Corpus work: 3cfacf2c-2b0b-528a-a1ba-b74fbe04e27e
DOI: 10.64898/2026.08.17.26360388

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