Article

The combined influence of viscoelasticity and adhesive cues on fibroblast spreading and focal adhesion formation

2021-02-17

Abstract excerpt

Tissue fibrosis is characterized by progressive extracellular matrix (ECM) stiffening and loss of viscoelasticity that ultimately results in reduced organ functionality. Cells bind to the ECM through integrins, where av integrin engagement in particular has been correlated with fibroblast activation into contractile myofibroblasts that drive fibrosis progression. There is a significant unmet need for in vitro hyd...

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Literature Corpus work: a8685537-3366-5353-bf33-cae84066911c
DOI: 10.1101/2021.02.17.430924

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