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Article

3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching.

Scientific reports - 24 Jul 2024

Han Yan, Shao Zehua, Zhang Yuanhao, Zhao Huan, Sun Zirui, Yang Chaokuan, Tang Hao, Han Yu, Gao Chuanyu

Abstract excerpt

This study investigates how dynamic fluctuations in matrix stiffness affect the behavior of cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment. Using hybrid hydrogels with tunable stiffness, we created an in vitro model to mimic the varying stiffness of the cardiac microenvironment. By manipulating hydrogel stiffness, we examined CF responses, particularly the expression of α-smooth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39043765
DOI: 10.1038/s41598-024-67646-x
PMCID: PMC11266583

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