Article
Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Jan 2024
Felisbino Marina B, Rubino Marcello, Travers Joshua G, Schuetze Katherine B, Lemieux Madeleine E, Anseth Kristi S, Aguado Brian A, McKinsey Timothy A
Abstract excerpt
In vitro cultures of primary cardiac fibroblasts (CFs), the major extracellular matrix (ECM)-producing cells of the heart, are used to determine molecular mechanisms of cardiac fibrosis. However, the supraphysiologic stiffness of tissue culture polystyrene (TCPS) triggers the conversion of CFs into an activated myofibroblast-like state, and serial passage of the cells results in the induction of replicative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.