Article

Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection

2019-09-24

Abstract excerpt

The interplay between a highly polymorphic set of MHC-I alleles and molecular chaperones shapes the repertoire of peptide antigens displayed on the cell surface for T cell surveillance. Here, we demonstrate that the molecular chaperone TAPBPR associates with a broad range of partially folded MHC-I species inside the cell. Bimolecular fluorescence complementation and deep mutational scanning reveal that TAPBPR reco...

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Literature Corpus work: 6f8ebce7-c595-536b-b020-3b1fe95e734a
DOI: 10.1101/779777

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