Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses.

Journal of molecular biology - 6 Dec 2019

Liu Yang, Cuendet Michel A, Goffin Laurence, Šachl Radek, Cebecauer Marek, Cariolato Luca, Guillaume Philippe, Reichenbach Patrick, Irving Melita, Coukos George, Luescher Immanuel F

Abstract excerpt

The coreceptor CD8αβ can greatly promote activation of T cells by strengthening T-cell receptor (TCR) binding to cognate peptide-MHC complexes (pMHC) on antigen presenting cells and by bringing p56Lck to TCR/CD3. Here, we demonstrate that CD8 can also bind to pMHC on the T cell (in cis) and that this inhibits their activation. Using molecular modeling, fluorescence resonance energy transfer experiments on living...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8 Antigens
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens

Share to Lymphocyte Activation

Share to Multiprotein Complexes

Share to Peptides

Share to Protein Interaction Domains and Motifs

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 31704286
DOI: 10.1016/j.jmb.2019.10.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses.PMID 31704286Read ↗

Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.Semantic proximity Read ↗

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.Semantic proximity Read ↗

Characterization of Human CD8αβ Interaction With Classical and Unconventional MHC Molecules.Semantic proximity Read ↗

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.Semantic proximity Read ↗

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read ↗

Design of high specificity binders for peptide-MHC-I complexesSemantic proximity Read ↗

Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry.Semantic proximity Read ↗

Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipidSemantic proximity Read ↗

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read ↗

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read ↗

T-cell receptor specificity maintained by altered thermodynamics.Semantic proximity Read ↗

SwiftTCR: Efficient computational docking protocol of TCRpMHC-I complexes using restricted rotation matricesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.