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Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte Dysfunction

14 Sept 2017

Abstract excerpt

Circadian rhythm disturbances are well established in neurological diseases. However, how these disruptions cause homeostatic imbalances remains poorly understood. Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) is a major circadian clock transcriptional activator, and Bmal1 deficiency in male Bmal1 nestin −/− mice induced marked astroglial activation without affecting the...

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PMID: 28912161
DOI: 10.1523/jneurosci.3639-16.2017

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