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Article

Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ+/- mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Dec 2020

Watson Ashley N, Berthiaume Andree-Anne, Faino Anna V, McDowell Konnor P, Bhat Narayan R, Hartmann David A, Shih Andy Y

Abstract excerpt

The receptor tyrosine kinase PDGFRβ is essential for pericyte migration to the endothelium. In mice lacking one allele of PDGFRβ (PDGFRβ+/-), previous reports have described an age-dependent loss of pericytes in the brain, leading to cerebrovascular dysfunction and subsequent neurodegeneration reminiscent of that seen in Alzheimer's disease and vascular dementia. We examined 12-20-month-old PDGFRβ+/- mice to...

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Identifiers

PMID: 31987006
DOI: 10.1177/0271678X19900543
PMCID: PMC7820684

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