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Article

The role of pericytic laminin in blood brain barrier integrity maintenance.

Scientific reports - 3 Nov 2016

Gautam Jyoti, Zhang Xuanming, Yao Yao

Abstract excerpt

Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been shown that laminin α4 (endothelial laminin) regulates vascular integrity at embryonic/neonatal stage, while astrocytic laminin maintains...

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Identifiers

PMID: 27808256
DOI: 10.1038/srep36450
PMCID: PMC5093438

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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