Article

Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal mice

2023-06-09

Abstract excerpt

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve heart failure (HF) outcomes across a range of patient characteristics. A hypothesis that SGLT2i induce metabolic change similar to fasting has recently been proposed to explain their profound clinical benefits. However, it remains unclear whether SGLT2i primarily induce this change in physiological settings. Here, we demonstrate that empagliflozin administ...

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Literature Corpus work: 3cad1692-bb8d-503e-ad88-c97f216d4855
DOI: 10.21203/rs.3.rs-3019728/v1

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