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Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans

3 Nov 2017

Abstract excerpt

High fat feeding impairs skeletal muscle metabolic flexibility and induces insulin resistance, whereas exercise training exerts positive effects on substrate handling and improves insulin sensitivity. To identify the genomic mechanisms by which exercise ameliorates some of the deleterious effects of high fat feeding, we investigated the transcriptional and epigenetic response of human skeletal muscle to 9 days of...

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PMID: 29123172
DOI: 10.1038/s41598-017-15420-7

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