Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes.

Frontiers in endocrinology - 1 Jan 2021

Pesta Dominik, Jelenik Tomas, Zaharia Oana-Patricia, Bobrov Pavel, Görgens Sven, Bódis Kálmán, Karusheva Yanislava, Krako Jakovljevic Nina, Lalic Nebojsa M, Markgraf Daniel F, Burkart Volker, Müssig Karsten, Knebel Birgit, Kotzka Jörg, Eckel Jürgen, Strassburger Klaus, Szendroedi Julia, Roden Michael

Abstract excerpt

The rs540467 SNP in the NDUFB6 gene, encoding a mitochondrial complex I subunit, has been shown to modulate adaptations to exercise training. Interaction effects with diabetes mellitus remain unclear. We assessed associations of habitual physical activity (PA) levels with metabolic variables and examined a possible modifying effect of the rs540467 SNP. Volunteers with type 2 (n=242), type 1 diabetes (n=250) or...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Composition
Share to Diabetes Mellitus, Type 2
Share to Electron Transport Complex I
Share to Exercise
Share to Germany
Share to Glucose Clamp Technique
Share to Longitudinal Studies
Share to Muscle, Skeletal

Source

Open in PubMed Open full text

Identifiers

PMID: 34659107
DOI: 10.3389/fendo.2021.693683
PMCID: PMC8518618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes.PMID 34659107Read ↗

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical ActivitySemantic proximity Read ↗

Functional dissection of metabolic trait-associated gene regulation in steady state and stimulated human skeletal muscle cellsSemantic proximity Read ↗

Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.Semantic proximity Read ↗

A single nucleotide polymorphism associates with the response of muscle ATP synthesis to long-term exercise training in relatives of type 2 diabetic humans.Semantic proximity Read ↗

Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes.Semantic proximity Read ↗

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake.Semantic proximity Read ↗

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle.Semantic proximity Read ↗

Exercise training, genetics and type 2 diabetes-related phenotypes.Semantic proximity Read ↗

Mitochondrial GWAS and association of nuclear – mitochondrial epistasis with BMI in T1DM patientsSemantic proximity Read ↗

Integrating SMRT and Bulk RNA Sequencing With Metabolic Phenotyping to Examine Reduced Skeletal Muscle Mitochondrial Respiration in Type 2 Diabetes.Semantic proximity Read ↗

Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal miceSemantic proximity Read ↗

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.