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Article

AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle.

Metabolism: clinical and experimental - 1 Oct 2021

Miller Spencer G, Hafen Paul S, Law Andrew S, Springer Catherine B, Logsdon David L, O'Connell Thomas M, Witczak Carol A, Brault Jeffrey J

Abstract excerpt

BACKGROUND: Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative capacity and broad alterations in metabolism that contribute to functional decline. However, the underlying mechanisms responsible for these metabolic changes are largely unknown. One of the most highly upregulated genes in atrophic muscle is...

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Identifiers

PMID: 34400216
DOI: 10.1016/j.metabol.2021.154864
PMCID: PMC8453098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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