Article

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

2022-05-05

Abstract excerpt

<title>Abstract</title> <p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential cofactor of critical enzymes including protein deacetylase Sirtuins/SIRTs and its levels in mammalian cells rely on the nicotinamide phosphoribosyltransferase (NAMPT)-mediated salvage pathway. Intracellular NAMPT (iNAMPT) is secreted and found in the blood as extracellular NAMPT (eNAMPT). In the liver, the iNAMPT-NAD<su...

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Literature Corpus work: d23dc5a6-42bc-501a-875f-5b34821645ad
DOI: 10.21203/rs.3.rs-1575385/v1

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