Article

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

2017-08-21

Abstract excerpt

<h4>ABSTRACT</h4> From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single S. cerevisiae cells treated with and without salt stress, to explore population variation and identify cellular covariate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c9f775b-72f4-5576-aa41-67a1d98b7f9d
DOI: 10.1101/179093

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stressDOI 10.1101/179093Read

Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress.Semantic proximity Read

Unstressed cells are alike, but stressed cells differ: Environmental and single-cell heterogeneity in yeast stress responsesSemantic proximity Read

Modeling single-cell phenotypes links yeast stress acclimation to transcriptional repression and pre-stress cellular states.Semantic proximity Read

Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses.Semantic proximity Read

Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant.Semantic proximity Read

Exploring transcription regulation through cell-to-cell variability.Semantic proximity Read

Genome-wide, time-sensitive interrogation of the heat shock response under diverse stressors via ReporterSeqSemantic proximity Read

Accumulation of cis- and trans-regulatory variations is associated with phenotypic divergence of a complex trait between yeast species.Semantic proximity Read

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness.Semantic proximity Read

Single cell functional genomics reveals the importance of mitochondria in cell-to-cell variation in proliferation, drug resistance and mutation outcomeSemantic proximity Read

Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise bufferingSemantic proximity Read

Time-Course Analysis of Gene Expression During theSaccharomyces cerevisiaeHypoxic ResponseSemantic proximity Read