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Article

Exploring transcription regulation through cell-to-cell variability.

Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2011

Rinott Ruty, Jaimovich Ariel, Friedman Nir

Abstract excerpt

The regulation of cellular protein levels is a complex process involving many regulatory mechanisms, each introducing stochastic events, leading to variability of protein levels between isogenic cells. Previous studies have shown that perturbing genes involved in transcription regulation affects the amount of cell-to-cell variability in protein levels, but to date there has been no systematic characterization of...

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PMID: 21444810
DOI: 10.1073/pnas.1013148108
PMCID: PMC3076844

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