Article
Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress.
PLoS biology - 1 Dec 2017
Gasch Audrey P, Yu Feiqiao Brian, Hose James, Escalante Leah E, Place Mike, Bacher Rhonda, Kanbar Jad, Ciobanu Doina, Sandor Laura, Grigoriev Igor V, Kendziorski Christina, Quake Stephen R, McClean Megan N
Abstract excerpt
From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae cells treated with and without salt stress to explore population variation and identify cellular covariates that...
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