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Article

Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction.

eLife - 12 Mar 2025

Boocock James, Alexander Noah, Alamo Tapia Leslie, Walter-McNeill Laura, Patel Shivani Prashant, Munugala Chetan, Bloom Joshua S, Kruglyak Leonid

Abstract excerpt

Expression quantitative trait loci (eQTLs) provide a key bridge between noncoding DNA sequence variants and organismal traits. The effects of eQTLs can differ among tissues, cell types, and cellular states, but these differences are obscured by gene expression measurements in bulk populations. We developed a one-pot approach to map eQTLs in Saccharomyces cerevisiae by single-cell RNA sequencing (scRNA-seq) and...

Read the complete abstract on PubMed

Topics

Quantitative Trait Loci
Saccharomyces cerevisiae
Single-Cell Analysis
Gene Expression Regulation, Fungal
Cell Cycle
Reproduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chromosome Mapping

Sequence Analysis, RNA

Alleles

Source

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Identifiers

PMID: 40073070
DOI: 10.7554/eLife.95566
PMCID: PMC11903034

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