Article
Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant.
PLoS biology - 1 Jan 2012
Levy Sasha F, Ziv Naomi, Siegal Mark L
Abstract excerpt
Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic gene expression results in cell-to-cell heterogeneity that might serve as a bet-hedging mechanism,...
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