Article

Induction of long-term hyperexcitability by memory-related cAMP signaling in isolated nociceptor cell bodies

2024-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Persistent hyperactivity of nociceptors is known to contribute significantly to long-lasting sensitization and ongoing pain in many clinical conditions. It is often assumed that nociceptor hyperactivity is mainly driven by continuing stimulation from inflammatory mediators. We have tested an additional possibility: that persistent increases in excitability promoting hyperactivity can be induced...

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Literature Corpus work: 3c4c38b9-b26f-58df-81a1-9742be1343e7
DOI: 10.1101/2024.07.13.603393

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