Article

Modelling inflammation-induced peripheral sensitization in a dish - more complex than expected?

2024-08-12

Abstract excerpt

Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem-cell derived sensory neurons. For this, we used a pre-existing and a novel stem cell line, modified to stably express the calcium sensor GCamP6f. Upon treatment with inflammatory soup, we observed no changes...

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Literature Corpus work: b9d1cee2-8f8d-50c9-8342-05ee4723e14f
DOI: 10.1101/2024.08.12.607558

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